WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: .05, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Fatty acid metabolism       ID:00071
C=43; O=8; E=0.05; R=148.59; rawP=4.92e-16; adjP=9.35e-15
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
6  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
7  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
8  ENSG00000072778 NA ACADVL acyl-CoA dehydrogenase, very long chain 37 ENSG00000072778


Database:KEGG pathway       Name:Peroxisome       ID:04146
C=79; O=6; E=0.10; R=60.66; rawP=7.50e-10; adjP=6.65e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
3  ENSG00000133835 NA HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 3295 ENSG00000133835
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000104823 NA ECH1 enoyl CoA hydratase 1, peroxisomal 1891 ENSG00000104823
6  ENSG00000166821 NA PEX11A peroxisomal biogenesis factor 11 alpha 8800 ENSG00000166821


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=13; E=1.41; R=9.19; rawP=1.05e-09; adjP=6.65e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000076555 NA ACACB acetyl-CoA carboxylase beta 32 ENSG00000076555
3  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
4  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
5  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
6  ENSG00000108784 NA NAGLU N-acetylglucosaminidase, alpha 4669 ENSG00000108784
7  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
8  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
9  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
10  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
11  ENSG00000123739 NA PLA2G12A phospholipase A2, group XIIA 81579 ENSG00000123739
12  ENSG00000133835 NA HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 3295 ENSG00000133835
13  ENSG00000072778 NA ACADVL acyl-CoA dehydrogenase, very long chain 37 ENSG00000072778


Database:KEGG pathway       Name:Valine, leucine and isoleucine degradation       ID:00280
C=44; O=5; E=0.06; R=90.76; rawP=2.66e-09; adjP=1.26e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
3  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
4  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315
5  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:KEGG pathway       Name:Propanoate metabolism       ID:00640
C=32; O=4; E=0.04; R=99.83; rawP=7.69e-08; adjP=2.92e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000076555 NA ACACB acetyl-CoA carboxylase beta 32 ENSG00000076555
3  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754


Database:KEGG pathway       Name:Fatty acid elongation in mitochondria       ID:00062
C=8; O=3; E=0.01; R=299.49; rawP=1.03e-07; adjP=3.26e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
3  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315


Database:KEGG pathway       Name:PPAR signaling pathway       ID:03320
C=70; O=4; E=0.09; R=45.64; rawP=1.89e-06; adjP=5.13e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
2  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
3  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
4  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:KEGG pathway       Name:Butanoate metabolism       ID:00650
C=30; O=3; E=0.04; R=79.86; rawP=7.35e-06; adjP=1.75e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
3  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:KEGG pathway       Name:Tryptophan metabolism       ID:00380
C=42; O=3; E=0.05; R=57.05; rawP=2.06e-05; adjP=4.35e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
3  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754


Database:KEGG pathway       Name:Synthesis and degradation of ketone bodies       ID:00072
C=9; O=2; E=0.01; R=177.48; rawP=5.51e-05; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
2  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:KEGG pathway       Name:Adipocytokine signaling pathway       ID:04920
C=68; O=3; E=0.09; R=35.23; rawP=8.78e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000076555 NA ACACB acetyl-CoA carboxylase beta 32 ENSG00000076555
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090


Database:KEGG pathway       Name:Terpenoid backbone biosynthesis       ID:00900
C=15; O=2; E=0.02; R=106.49; rawP=0.0002; adjP=0.0003
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
2  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:KEGG pathway       Name:beta-Alanine metabolism       ID:00410
C=22; O=2; E=0.03; R=72.60; rawP=0.0003; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754


Database:KEGG pathway       Name:Pyruvate metabolism       ID:00620
C=40; O=2; E=0.05; R=39.93; rawP=0.0012; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000076555 NA ACACB acetyl-CoA carboxylase beta 32 ENSG00000076555
2  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437


Database:KEGG pathway       Name:Fat digestion and absorption       ID:04975
C=46; O=2; E=0.06; R=34.72; rawP=0.0015; adjP=0.0018
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000123739 NA PLA2G12A phospholipase A2, group XIIA 81579 ENSG00000123739
2  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437


Database:KEGG pathway       Name:Lysine degradation       ID:00310
C=44; O=2; E=0.06; R=36.30; rawP=0.0014; adjP=0.0018
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120437 NA ACAT2 acetyl-CoA acetyltransferase 2 39 ENSG00000120437
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754


Database:KEGG pathway       Name:Amyotrophic lateral sclerosis (ALS)       ID:05014
C=53; O=2; E=0.07; R=30.14; rawP=0.0020; adjP=0.0022
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
2  ENSG00000197442 NA MAP3K5 mitogen-activated protein kinase kinase kinase 5 4217 ENSG00000197442


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=2; E=0.17; R=11.57; rawP=0.0130; adjP=0.0137
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000076555 NA ACACB acetyl-CoA carboxylase beta 32 ENSG00000076555
2  ENSG00000044446 NA PHKA2 phosphorylase kinase, alpha 2 (liver) 5256 ENSG00000044446


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=2; E=0.34; R=5.96; rawP=0.0446; adjP=0.0446
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000123739 NA PLA2G12A phospholipase A2, group XIIA 81579 ENSG00000123739
2  ENSG00000197442 NA MAP3K5 mitogen-activated protein kinase kinase kinase 5 4217 ENSG00000197442




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).